A police officer has been killed in Victoria’s east after her motorcycle and a four-wheel-drive vehicle collided.

The collision on the Princes Highway near Lindenow South, 20 kilometres from Bairnsdale in Gippsland, occurred about 7am on Wednesday and was being investigated by the police major collision unit.

It is understood the 53-year-old officer was travelling to work in Sale.

The male driver of the 4WD vehicle, who is believed to be a Gippsland-based doctor, was assisting police with their inquiries.

The Princes Highway was blocked in both directions, with traffic diverted at Benworden Road.

Police confirmed the victim was a senior constable from an Eastern Region police station but made no further comment.

Anyone with information about the crash is urged to contact Crime Stoppers on1800 333 000.